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Traditionally administered in-person, restrictions imposed by the COVID-19 pandemic prompted the National Survey on Drug Use and Health to transition to a multimode survey that offers a self-administered web option prior to in-person data collection. A relatively small portion of respondents who began the survey on the web but broke off prior to completing were later readministered the survey (from the beginning) in-person. We refer to these as “second chance” respondents. The aim of this in-brief note is to report the individual-level mode discrepancies these second chance respondents exhibited with respect to lifetime use of cigarettes, alcohol, and marijuana. In addition to higher-than-anticipated discrepancy rates overall, we found directional differences that run contrary to what would be expected from the literature on survey mode effects.